{
  "updated": "2026-09-19",
  "scope": "Scientific evidence relevant to BHOC and transplant oxygen delivery. These records are external transplantation studies and are not BHOC efficacy evidence.",
  "records": [
    {
      "id": "TR-REL-2026-001",
      "organ": "Liver",
      "modality": "HOPE / preservation",
      "evidenceType": "Meta-analysis of randomized trials",
      "title": "Hypothermic Oxygenated Perfusion Versus Static Cold Storage in Liver Transplantation: A Meta-Analysis of Randomized Trials",
      "year": 2026,
      "authors": "Ellouze A, Tzedakis S, Zorkot MA, et al.",
      "journal": "Clinical Transplantation",
      "population": "8 randomized trials; 984 adult liver transplant recipients",
      "signal": "HOPE was associated with lower early allograft dysfunction, primary non-function, major complications and biliary complications than static cold storage; one-year graft survival was comparable.",
      "relevance": "Directly relevant to oxygenated preservation, ischemia-reperfusion injury and measurable graft outcomes.",
      "boundary": "Not a BHOC study and does not establish a role for BHOC in perfusion.",
      "doi": "10.1111/ctr.70676",
      "pmid": "42717689",
      "doiUrl": "https://doi.org/10.1111/ctr.70676",
      "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42717689/"
    },
    {
      "id": "TR-REL-2026-002",
      "organ": "Kidney",
      "modality": "Hypothermic machine perfusion",
      "evidenceType": "Single-center retrospective cohort",
      "title": "Machine Perfusion Parameters and 1-Year Outcomes in High KDPI Kidney Transplantation: A Single-Center Cohort Study",
      "year": 2026,
      "authors": "Foster CE, Filardi KFXC, Hanna J, Dar W, Emmanuel B, Morgan G, Serrano OK",
      "journal": "Transplantation Proceedings",
      "population": "71 recipients of kidneys with KDPI ≥85",
      "signal": "Pre-specified machine-perfusion flow and resistance groups did not show statistically significant differences in one-year renal function, graft survival or patient survival.",
      "relevance": "Supports testing whether perfusion measurements are meaningful surrogates for tissue-level benefit and graft function.",
      "boundary": "Observational single-center evidence; not a BHOC or oxygen-carrier study.",
      "doi": "10.1016/j.transproceed.2026.07.036",
      "pmid": "42731909",
      "doiUrl": "https://doi.org/10.1016/j.transproceed.2026.07.036",
      "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42731909/"
    },
    {
      "id": "TR-REL-2026-003",
      "organ": "Lung",
      "modality": "TA-NRP / procurement",
      "evidenceType": "OPTN retrospective analysis",
      "title": "Early-to-Midterm Outcomes of Lung Transplantation Following Procurement with Thoracoabdominal Regional Perfusion: An OPTN Analysis",
      "year": 2026,
      "authors": "O'Neill J, Gregorio PHP, Hassaballa A, et al.",
      "journal": "The Journal of Heart and Lung Transplantation",
      "population": "DCD lung transplantation; 1364 standard rapid recovery and 261 TA-NRP recipients",
      "signal": "One- and three-year survival were comparable. After adjustment, TA-NRP recipients had lower odds of ECMO use at 72 hours.",
      "relevance": "Relevant to regional perfusion, procurement physiology, preservation and oxygen-delivery questions across organs.",
      "boundary": "Registry evidence; not a BHOC or oxygen-carrier study.",
      "doi": "10.1016/j.healun.2026.09.005",
      "pmid": "42731647",
      "doiUrl": "https://doi.org/10.1016/j.healun.2026.09.005",
      "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42731647/"
    },
    {
      "id": "TR-REL-2026-004",
      "organ": "Liver",
      "modality": "HOPE vs NMP",
      "evidenceType": "International real-world cohort",
      "title": "Real-World Analysis of Hypothermic Oxygenated Perfusion and Normothermic Machine Perfusion in Liver Transplantation: An International Cohort Study",
      "year": 2026,
      "authors": "Pfister M, Eden J, Rasel H, et al.",
      "journal": "Annals of Surgery",
      "population": "954 NMP-treated and 1202 HOPE-treated liver grafts",
      "signal": "The study compared contemporary HOPE and NMP practice across international cohorts with substantial baseline donor-risk differences and risk-adjusted analyses.",
      "relevance": "Relevant to how different oxygenated perfusion strategies are selected, measured and compared in real-world transplantation.",
      "boundary": "Non-randomized real-world comparison; not BHOC evidence.",
      "doi": "10.1097/SLA.0000000000007195",
      "pmid": "42684111",
      "doiUrl": "https://doi.org/10.1097/SLA.0000000000007195",
      "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42684111/"
    },
    {
      "id": "TR-REL-2026-005",
      "organ": "Liver",
      "modality": "Normothermic machine perfusion",
      "evidenceType": "Multicenter registry study",
      "title": "Real-World Use of Normothermic Machine Perfusion in Liver Transplantation: A Multi-Institutional Experience From the National Organ Perfusion Registry",
      "year": 2026,
      "authors": "Cortez AR, Loh WS, Sheskey S, et al.",
      "journal": "Clinical Transplantation",
      "population": "545 NMP liver transplants across nine U.S. centers",
      "signal": "The registry described diverse NMP practice and reported a 90-day death-censored graft failure rate of 1.7%.",
      "relevance": "Relevant to deployment, perfusion logistics, viability assessment and outcome measurement in contemporary machine perfusion.",
      "boundary": "Descriptive multicenter registry evidence without a randomized control group; not BHOC evidence.",
      "doi": "10.1111/ctr.70664",
      "pmid": "42672047",
      "doiUrl": "https://doi.org/10.1111/ctr.70664",
      "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42672047/"
    }
  ]
}