Prehospital & trauma
Blood access, emergency transfusion, transport time, hemorrhage and the oxygen-delivery gap before definitive care.
Open Prehospital EMS →Knowledge Base · Real-World Evidence
Oxygen Delivery Evidence
A public knowledge-base section for evidence, context and analysis beyond direct BHOC / HBOC product records. It connects donor blood and transfusion comparators, blood-group compatibility, tissue oxygenation, hypoxia and ischemia, microcirculation, emergency care and broader oxygen-delivery science.
Latest additionBlood Groups: From ABO to 49 Blood Group Systems →
Evidence domains
Read the clinical problem before the technology.
Postpartum hemorrhage
Maternal bleeding, donor-blood access, time-critical resuscitation and oxygen-delivery context.
Open PPH evidence →Donor blood & transfusion
Blood availability, compatibility, transfusion thresholds, donor-system constraints and the increasing complexity of blood-group science.
Blood Groups: ABO → 49 systems new →Microcirculation & tissue oxygenation
Flow, diffusion, extraction, endothelial biology and the difference between circulating oxygen metrics and tissue delivery.
Open oxygen-delivery science →Human-use context
Clinical and translational evidence across anemia, emergency care, surgery, ischemia and critical care.
Open Human Use →Transplantation & perfusion
Preservation, machine perfusion, viability assessment, reperfusion and oxygen delivery across the graft journey.
Open Transplantation →Section directory
All Real-World Evidence routes in one place.
This directory exposes every current subsection connected to Real-World Evidence so readers and search engines can move from the broad clinical context to the underlying evidence, analysis and research questions without returning to the main platform each time.
Activity dates: “Added” marks a new BHOC knowledge-base page; “Updated” reflects the latest verified page update in the repository. These dates are not the publication dates of the underlying scientific sources.
Prehospital & trauma
- Prehospital EMS & Emergency Blood Transfusion →Programs, blood access, logistics and the prehospital oxygen-delivery gap.
- Prehospital transfusion & oxygen-delivery analysis →Scientific framing of blood transfusion and oxygen-delivery endpoints.
- Are we identifying the oxygen-delivery problem early enough? →Research concept on prehospital selection signals and treatment window.
Postpartum hemorrhage
- PPH · Maternal Emergency & Blood Access →Time-critical maternal hemorrhage, access constraints and oxygen delivery.
- PPH oxygen-delivery window →Research concept separating blood loss from the evolving oxygen-delivery deficit.
Comparator evidence
- Blood Groups: From ABO to 49 Systems new →Concise source-linked history and the current ISBT classification.
- RBC transfusion thresholds & oxygen delivery →Modern restrictive thresholds, patient context and limits of a number-only approach.
Microcirculation & tissue oxygenation
- Oxygen-delivery potency →Functional oxygen delivery versus concentration alone.
- NO scavenging, vasoconstriction & HBOC physiology →Vascular response, nitric oxide and tissue oxygenation.
- Sepsis, microcirculation & tissue oxygenation →Why systemic values may not fully represent microvascular oxygen delivery.
- Nobel foundations in oxygen biology →Scientific milestones relevant to oxygen sensing, metabolism and physiology.
Human-use context
- Human-Use Evidence Hub →Clinical and separately labelled translational evidence.
- Human publication search →Search records by direction, institution, author, journal and historical term.
- FDA Expanded Access · HBOC-201 / Hemopure →Official access and regulatory context.
Transplantation & perfusion
- Transplantation Evidence Hub →Kidney, liver, heart, limb and cross-organ evidence.
- Transplantation publication search →Search HBOC/BHOC evidence across preservation, perfusion and reperfusion.
Evidence boundary
Separate direct product evidence from the world around it.
Real-World Evidence is the broader evidence layer. Direct BHOC / HBOC records, regulatory history and publication libraries remain in the BHOC Therapeutics Platform. Comparator evidence, clinical-system constraints and oxygen-delivery context are kept distinct so that evidence can be traced without blending product claims with the clinical environment.
BHOC ecosystem
Clear public routes. No code repositories.
This knowledge-base entry is scientific and educational. Inclusion of evidence does not establish efficacy, regulatory approval or a clinical recommendation.