This layer tracks transplantation research that helps define testable oxygen-delivery questions across organ preservation, machine perfusion, regional perfusion, viability assessment and ischemia-reperfusion. It is intentionally separate from the historical HBOC / Hemopure publication catalogue.
The established catalogue preserves source-linked records that directly discuss historical oxygen carriers, HBOC-201, Hemopure or closely related perfusion work.
Search the historical catalogue →This separate catalogue follows transplantation studies that do not test BHOC but clarify where oxygen delivery, preservation, perfusion metrics and reperfusion injury can be measured.
Open data layer →The counts below refer only to the new external evidence layer. They do not alter the 53-record historical HBOC catalogue.
HOPE, NMP, preservation, donor-risk selection and real-world perfusion practice.
Hypothermic machine perfusion parameters and one-year transplant outcomes.
Thoracoabdominal regional perfusion and DCD lung procurement outcomes.
HOPE versus static cold storage and ischemia-reperfusion-related outcomes.
NMP/HMP as measurable platforms for organ support, assessment and selection.
NRP/TA-NRP as an organ-procurement and reperfusion physiology context.
The value of this evidence layer is not to imply BHOC efficacy. It is to identify established transplantation workflows in which oxygen availability, perfusion quality, tissue injury and graft function are measurable.
Future BHOC research would need its own safety, formulation, dosing, perfusion and graft-outcome evidence. External transplantation studies cannot substitute for that evidence.
Primary DOI and PubMed routes are provided when available. Each record separates the reported finding from its relevance to future BHOC research.
Population: 8 randomized trials, 984 adult recipients.
Reported signal: HOPE was associated with lower early allograft dysfunction, primary non-function, major complications and biliary complications; one-year graft survival was comparable.
BHOC relevance: establishes a strong oxygenated-preservation context for studying ischemia-reperfusion and graft outcomes.
Population: 71 recipients of kidneys with KDPI ≥85.
Reported signal: the prespecified flow/resistance groups did not show statistically significant differences in one-year renal function, graft survival or patient survival.
BHOC relevance: useful for separating machine readouts from endpoints that reflect actual graft function and tissue benefit.
Population: DCD lung transplantation comparing 1,364 standard rapid recovery and 261 TA-NRP recipients.
Reported signal: one- and three-year survival were comparable; adjusted analysis found lower odds of ECMO use at 72 hours in the TA-NRP group.
BHOC relevance: expands the evidence map into regional perfusion and organ-procurement physiology.
Population: 954 NMP-treated and 1,202 HOPE-treated liver grafts.
Reported signal: real-world HOPE and NMP cohorts were compared with risk adjustment, while substantial donor-risk and practice differences remained important to interpretation.
BHOC relevance: shows how oxygenated perfusion strategies are selected and evaluated in contemporary practice.
Population: 545 NMP liver transplants across nine U.S. centers.
Reported signal: NMP was used across diverse donor and logistical settings; 90-day death-censored graft failure was reported at 1.7%.
BHOC relevance: relevant to deployment, perfusion logistics, viability assessment and endpoint selection.
This layer should expand only when a source adds a meaningful transplant oxygen-delivery question: perfusate oxygen-carrying capacity, tissue oxygenation, mitochondrial or microvascular response, viability metrics, ischemia-reperfusion injury, delayed graft function, post-reperfusion syndrome, or organ-specific oxygen demand.
Heart and additional organ directions remain open for future verified evidence. Records should be added by source, not to fill a quota.
Separation rule: Historical/direct HBOC evidence stays in Transplant-publications.json. External transplantation science relevant to future BHOC research stays in Transplant-relevant-evidence.json.